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The following articles relating to nanotechnology may be found on the website of How Stuff Works: www.howstuffworks.com
How Nanotechnology Works
by Kevin Bonsor and Jonathan Strickland
Introduction to How Nanotechnology Works
There's an unprecedented multidisciplinary convergence of scientists dedicated to the study of a world so small, we can't see it -- even with a light microscope. That world is the field of nanotechnology, the realm of atoms and nanostructures. Nanotechnology is so new, no one is really sure what will come of it. Even so, predictions range from the ability to reproduce things like diamonds and food to the world being devoured by self-replicating nanorobots.
In order to understand the unusual world of nanotechnology, we need to get an idea of the units of measure involved. A centimeter is one-hundredth of a meter, a millimeter is one-thousandth of a meter, and a micrometer is one-millionth of a meter, but all of these are still huge compared to the nanoscale. A nanometer (nm) is one-billionth of a meter, smaller than the wavelength of visible light and a hundred-thousandth the width of a human hair [source: Berkeley Lab].
Video Gallery: Nanotechnology
Nanotechnology deals with materials and machines on an incredibly tiny scale -- less than one billionth of a meter. To learn more about nanotechnology, check out this HowStuffWorks video.
As small as a nanometer is, it's still large compared to the atomic scale. An atom has a diameter of about 0.1 nm. An atom's nucleus is much smaller -- about 0.00001 nm. Atoms are the building blocks for all matter in our universe. You and everything around you are made of atoms. Nature has perfected the science of manufacturing matter molecularly. For instance, our bodies are assembled in a specific manner from millions of living cells. Cells are nature's nanomachines. At the atomic scale, elements are at their most basic level. On the nanoscale, we can potentially put these atoms together to make almost anything.
In a lecture called "Small Wonders:The World of Nanoscience," Nobel Prize winner Dr. Horst Störmer said that the nanoscale is more interesting than the atomic scale because the nanoscale is the first point where we can assemble something -- it's not until we start putting atoms together that we can make anything useful.
In this article, we'll learn about what nanotechnology means today and what the future of nanotechnology may hold. We'll also look at the potential risks that come with working at the nanoscale.
In the next section, we'll learn more about our world on the nanoscale.
How New is Nanotechnology?
In 1959, physicist and future Nobel prize winner Richard Feynman gave a lecture to the American Physical Society called "There's Plenty of Room at the Bottom." The focus of his speech was about the field of miniaturization and how he believed man would create increasingly smaller, powerful devices.
In 1986, K. Eric Drexler wrote "Engines of Creation" and introduced the term nanotechnology. Scientific research really expanded over the last decade. Inventors and corporations aren't far behind -- today, more than 13,000 patents registered with the U.S. Patent Office have the word "nano" in them [source: U.S. Patent and Trademark Office].
The World of Nanotechnology
Experts sometimes disagree about what constitutes the nanoscale, but in general, you can think of nanotechnology dealing with anything measuring between 1 and 100 nm. Larger than that is the microscale, and smaller than that is the atomic scale.
Sam Yesh/AFP/Getty Images
An engineer prepares a silicon wafer in an early stage of microchip production.
Nanotechnology is rapidly becoming an interdisciplinary field. Biologists, chemists, physicists and engineers are all involved in the study of substances at the nanoscale. Dr. Störmer hopes that the different disciplines develop a common language and communicate with one another [source: Störmer]. Only then, he says, can we effectively teach nanoscience since you can't understand the world of nanotechnology without a solid background in multiple sciences.
One of the exciting and challenging aspects of the nanoscale is the role that quantum mechanics plays in it. The rules of quantum mechanics are very different from classical physics, which means that the behavior of substances at the nanoscale can sometimes contradict common sense by behaving erratically. You can't walk up to a wall and immediately teleport to the other side of it, but at the nanoscale an electron can -- it's called electron tunneling. Substances that are insulators, meaning they can't carry an electric charge, in bulk form might become semiconductors when reduced to the nanoscale. Melting points can change due to an increase in surface area. Much of nanoscience requires that you forget what you know and start learning all over again.
So what does this all mean? Right now, it means that scientists are experimenting with substances at the nanoscale to learn about their properties and how we might be able to take advantage of them in various applications. Engineers are trying to use nano-size wires to create smaller, more powerful microprocessors. Doctors are searching for ways to use nanoparticles in medical applications. Still, we've got a long way to go before nanotechnology dominates the technology and medical markets.
In the next section, we'll look at two important nanotechnology structures: nanowires and carbon nanotubes.
It's a Small World After All
At the nanoscale, objects are so small that we can't see them -- even with a light microscope. Nanoscientists have to use tools like scanning tunneling microscopes or atomic force microscopes to observe anything at the nanoscale. Scanning tunneling microscopes use a weak electric current to probe the scanned material. Atomic force microscopes scan surfaces with an incredibly fine tip. Both microscopes send data to a computer, which can assemble the information and project it graphically onto a monitor [source: Encyclopædia Britannica].
Nanowires and Carbon Nanotubes
Currently, scientists find two nano-size structures of particular interest: nanowires and carbon nanotubes. Nanowires are wires with a very small diameter, sometimes as small as 1 nanometer. Scientists hope to use them to build tiny transistors for computer chips and other electronic devices. In the last couple of years, carbon nanotubes have overshadowed nanowires. We're still learning about these structures, but what we've learned so far is very exciting.
A carbon nanotube is a nano-size cylinder of carbon atoms. Imagine a sheet of carbon atoms, which would look like a sheet of hexagons. If you roll that sheet into a tube, you'd have a carbon nanotube. Carbon nanotube properties depend on how you roll the sheet. In other words, even though all carbon nanotubes are made of carbon, they can be very different from one another based on how you align the individual atoms.
With the right arrangement of atoms, you can create a carbon nanotube that's hundreds of times stronger than steel, but six times lighter [source: The Ecologist]. Engineers plan to make building material out of carbon nanotubes, particularly for things like cars and airplanes. Lighter vehicles would mean better fuel efficiency, and the added strength translates to increased passenger safety.
Carbon nanotubes can also be effective semiconductors with the right arrangement of atoms. Scientists are still working on finding ways to make carbon nanotubes a realistic option for transistors in microprocessors and other electronics.
In the next section, we'll look at products that are taking advantage of nanotechnology.
Graphite vs. Diamonds
What's the difference between graphite and diamonds? Both materials are made of carbon, but both have vastly different properties. Graphite is soft; diamonds are hard. Graphite conducts electricity, but diamonds are insulators and can't conduct electricity. Graphite is opaque; diamonds are usually transparent. Graphite and diamonds have these properties because of the way the carbon atoms bond together at the nanoscale.
Products with Nanotechnology
You might be surprised to find out how many products on the market are already benefiting from nanotechnology.
· Greg Wood/AFP/Getty Images
Ingredients like zinc oxide can leave a white sheen behind. But sunscreens with zinc oxide nanoparticles rub on clear.
· Sunscreen - Many sunscreens contain nanoparticles of zinc oxide or titanium oxide. Older sunscreen formulas use larger particles, which is what gives most sunscreens their whitish color. Smaller particles are less visible, meaning that when you rub the sunscreen into your skin, it doesn't give you a whitish tinge.
· Self-cleaning glass - A company called Pilkington offers a product they call Activ Glass, which uses nanoparticles to make the glass photocatalytic and hydrophilic. The photocatalytic effect means that when UV radiation from light hits the glass, nanoparticles become energized and begin to break down and loosen organic molecules on the glass (in other words, dirt). Hydrophilic means that when water makes contact with the glass, it spreads across the glass evenly, which helps wash the glass clean.
· Clothing - Scientists are using nanoparticles to enhance your clothing. By coating fabrics with a thin layer of zinc oxide nanoparticles, manufacturers can create clothes that give better protection from UV radiation. Some clothes have nanoparticles in the form of little hairs or whiskers that help repel water and other materials, making the clothing stain-resistant.
· Yoshikazu Tsuno/AFP/Getty Images
Bridgestone engineers developed this Quick Response Liquid Powder Display, a flexible digital screen, using nanotechnology.
· Scratch-resistant coatings - Engineers discovered that adding aluminum silicate nanoparticles to scratch-resistant polymer coatings made the coatings more effective, increasing resistance to chipping and scratching. Scratch-resistant coatings are common on everything from cars to eyeglass lenses.
· Antimicrobial bandages - Scientist Robert Burrell created a process to manufacture antibacterial bandages using nanoparticles of silver. Silver ions block microbes' cellular respiration [source: Burnsurgery.org]. In other words, silver smothers harmful cells, killing them.
· Swimming pool cleaners and disinfectants - EnviroSystems, Inc. developed a mixture (called a nanoemulsion) of nano-sized oil drops mixed with a bactericide. The oil particles adhere to bacteria, making the delivery of the bactericide more efficient and effective.
[source: The Ecologist]
New products incorporating nanotechnology are coming out every day. Wrinkle-resistant fabrics, deep-penetrating cosmetics, liquid crystal displays (LCD) and other conveniences using nanotechnology are on the market. Before long, we'll see dozens of other products that take advantage of nanotechnology ranging from Intel microprocessors to bio-nanobatteries, capacitors only a few nanometers thick. While this is exciting, it's only the tip of the iceberg as far as how nanotechnology may impact us in the future.
In the next section, we'll look at some of the incredible things that nanotechnology may hold for us.
Tennis, Anyone?
Nanotechnology is making a big impact on the tennis world. In 2002, the tennis racket company Babolat introduced the VS Nanotube Power racket. They made the racket out of carbon nanotube-infused graphite, meaning the racket was very light, yet many times stronger than steel. Meanwhile, tennis ball manufacturer Wilson introduced the Double Core tennis ball. These balls have a coating of clay nanoparticles on the inner core. The clay acts as a sealant, making it very difficult for air to escape the ball.
The Future of Nanotechnology
In the world of "Star Trek," machines called replicators can produce practically any physical object, from weapons to a steaming cup of Earl Grey tea. Long considered to be exclusively the product of science fiction, today some people believe replicators are a very real possibility. They call it molecular manufacturing, and if it ever does become a reality, it could drastically change the world.
Atoms and molecules stick together because they have complementary shapes that lock together, or charges that attract. Just like with magnets, a positively charged atom will stick to a negatively charged atom. As millions of these atoms are pieced together by nanomachines, a specific product will begin to take shape. The goal of molecular manufacturing is to manipulate atoms individually and place them in a pattern to produce a desired structure.
The first step would be to develop nanoscopic machines, called assemblers, that scientists can program to manipulate atoms and molecules at will. Rice University Professor Richard Smalley points out that it would take a single nanoscopic machine millions of years to assemble a meaningful amount of material. In order for molecular manufacturing to be practical, you would need trillions of assemblers working together simultaneously. Eric Drexler believes that assemblers could first replicate themselves, building other assemblers. Each generation would build another, resulting in exponential growth until there are enough assemblers to produce objects [source: Ray Kurzweil].
Assemblers might have moving parts like the nanogears
in this concept drawing.
Trillions of assemblers and replicators could fill an area smaller than a cubic millimeter, and could still be too small for us to see with the naked eye. Assemblers and replicators could work together to automatically construct products, and could eventually replace all traditional labor methods. This could vastly decrease manufacturing costs, thereby making consumer goods plentiful, cheaper and stronger. Eventually, we could be able to replicate anything, including diamonds, water and food. Famine could be eradicated by machines that fabricate foods to feed the hungry.
Nanotechnology may have its biggest impact on the medical industry. Patients will drink fluids containing nanorobots programmed to attack and reconstruct the molecular structure of cancer cells and viruses. There's even speculation that nanorobots could slow or reverse the aging process, and life expectancy could increase significantly. Nanorobots could also be programmed to perform delicate surgeries -- such nanosurgeons could work at a level a thousand times more precise than the sharpest scalpel [source: International Journal of Surgery]. By working on such a small scale, a nanorobot could operate without leaving the scars that conventional surgery does. Additionally, nanorobots could change your physical appearance. They could be programmed to perform cosmetic surgery, rearranging your atoms to change your ears, nose, eye color or any other physical feature you wish to alter.
Nanotechnology has the potential to have a positive effect on the environment. For instance, scientists could program airborne nanorobots to rebuild the thinning ozone layer. Nanorobots could remove contaminants from water sources and clean up oil spills. Manufacturing materials using the bottom-up method of nanotechnology also creates less pollution than conventional manufacturing processes. Our dependence on non-renewable resources would diminish with nanotechnology. Cutting down trees, mining coal or drilling for oil may no longer be necessary -- nanomachines could produce those resources.
Many nanotechnology experts feel that these applications are well outside the realm of possibility, at least for the foreseeable future. They caution that the more exotic applications are only theoretical. Some worry that nanotechnology will end up like virtual reality -- in other words, the hype surrounding nanotechnology will continue to build until the limitations of the field become public knowledge, and then interest (and funding) will quickly dissipate.
In the next section, we'll look at some of the challenges and risks of nanotechnology.
Nanotechnology Challenges, Risks and Ethics
The most immediate challenge in nanotechnology is that we need to learn more about materials and their properties at the nanoscale. Universities and corporations across the world are rigorously studying how atoms fit together to form larger structures. We're still learning about how quantum mechanics impact substances at the nanoscale.
Because elements at the nanoscale behave differently than they do in their bulk form, there's a concern that some nanoparticles could be toxic. Some doctors worry that the nanoparticles are so small, that they could easily cross the blood-brain barrier, a membrane that protects the brain from harmful chemicals in the bloodstream. If we plan on using nanoparticles to coat everything from our clothing to our highways, we need to be sure that they won't poison us.
Closely related to the knowledge barrier is the technical barrier. In order for the incredible predictions regarding nanotechnology to come true, we have to find ways to mass produce nano-size products like transistors and nanowires. While we can use nanoparticles to build things like tennis rackets and make wrinkle-free fabrics, we can't make really complex microprocessor chips with nanowires yet.
Apocalyptic Goo
Eric Drexler, the man who introduced the word nanotechnology, presented a frightening apocalyptic vision -- self-replicating nanorobots malfunctioning, duplicating themselves a trillion times over, rapidly consuming the entire world as they pull carbon from the environment to build more of themselves. It's called the "grey goo" scenario, where a synthetic nano-size device replaces all organic material. Another scenario involves nanodevices made of organic material wiping out the Earth -- the "green goo" scenario.
There are some hefty social concerns about nanotechnology too. Nanotechnology may also allow us to create more powerful weapons, both lethal and non-lethal. Some organizations are concerned that we'll only get around to examining the ethical implications of nanotechnology in weaponry after these devices are built. They urge scientists and politicians to examine carefully all the possibilities of nanotechnology before designing increasingly powerful weapons.
If nanotechnology in medicine makes it possible for us to enhance ourselves physically, is that ethical? In theory, medical nanotechnology could make us smarter, stronger and give us other abilities ranging from rapid healing to night vision. Should we pursue such goals? Could we continue to call ourselves human, or would we become transhuman -- the next step on man's evolutionary path? Since almost every technology starts off as very expensive, would this mean we'd create two races of people -- a wealthy race of modified humans and a poorer population of unaltered people? We don't have answers to these questions, but several organizations are urging nanoscientists to consider these implications now, before it becomes too late.
Not all questions involve altering the human body -- some deal with the world of finance and economics. If molecular manufacturing becomes a reality, how will that impact the world's economy? Assuming we can build anything we need with the click of a button, what happens to all the manufacturing jobs? If you can create anything using a replicator, what happens to currency? Would we move to a completely electronic economy? Would we even need money?
Whether we'll actually need to answer all of these questions is a matter of debate. Many experts think that concerns like grey goo and transhumans are at best premature, and probably unnecessary. Even so, nanotechnology will definitely continue to impact us as we learn more about the enormous potential of the nanoscale.
The following articles relating to biotechnology and genetic engineering may be found on the website of the Union of Concerned Scientists: www.ucsusa.org
What Is Biotechnology?
Biotechnology is a broad term that applies to all practical uses of living organisms—anything from microorganisms used in the fermentation of beer to the most sophisticated application of gene therapy. The term covers applications that are old and new, familiar and strange, sophisticated and simple.
Defined in this way, the term is almost too broad to be useful. One way of thinking about biotechnology is to consider two categories of activities: those that are traditional and familiar and those that are relatively new. Within each category can be found technologies that are genetic—that involve modifications of traits passed down from one generation to the next—and technologies that are not.
Although there are interesting issues connected with a number of biotechnologies—both old and new—most of UCS's work focuses on genetic engineering, a new genetic biotechnology.
Traditional Biotechnologies
A prime example of traditional genetic biotechnologies is selective breeding of plants and animals. The rudiments of selecting plants and animals with desirable traits and breeding them under controlled conditions probably go back to the dawn of civilization, but the expansion of knowledge about genetics and biology in this century has developed selective breeding into a powerful and sophisticated technology. New molecular approaches like marker-assisted breeding (which enhances traditional breeding through knowledge of which cultivars or breeds carry which trait) promise to enhance these approaches even further.
Traditional breeding technologies have been immensely successful, and indeed are largely responsible for the high yields associated with contemporary agriculture. These technologies should not be considered passé or out of date. For multigene traits like intrinsic yield and drought resistance, they surpass genetic engineering. This is because selective breeding operates on whole organisms—complete sets of coordinated genes—while genetic engineering is restricted to three or four gene transfers with little control over where the new genes are inserted. For the most important agronomic traits, traditional breeding remains the technology of choice.
Other traditional nongenetic biotechnologies include the fermentation of microorganisms to produce wine, beer, and cheese. Industry also uses microorganisms to produce various products such as enzymes for use in laundry detergents. In an effort to find microorganisms that produce large amounts of enzymes, scientists sometimes treat a batch of organisms with radiation or chemicals to randomly produce genetic alternations. The process, called mutagenesis, produces numerous genetic changes in the bacteria, among which might be a few that produce more of the desired product.
New Biotechnologies
Many new biotechnologies do not involve modifications of traits passed on to the next generation. A good example is monoclonal antibodies (highly specific preparations of antibodies that bind to a single site on a protein), which have many diagnostic applications, including home pregnancy testing kits. Many biotechnology companies are engaged in these sophisticated, but noncontroversial, technologies.
By contrast, mammalian cloning is a new biotechnology that does not involve gene modification, but is nevertheless highly controversial. Cloning reproduces adult mammals by transplanting a nucleus from adult cells into an egg from which the nucleus has been removed and allowing the egg to develop in a surrogate manner. The resulting individuals are as similar to the adults from which the nuclei were taken as identical twins are to one another. Although this procedure has profound implications for human reproduction, it does not modify specific traits of an individual, but rather transfers a whole nucleus containing a complete set of genetic information.
The new technology that can affect future generations is genetic engineering, a technology based on the artificial manipulation and transfer of genetic material. This technology can move genes and the traits they dictate across natural boundaries—from one type of plant to another, from one type of animal to another, and even from a plant to an animal or an animal to a plant. Cells modified by these techniques pass the new genes and traits on to their offspring. Genetic engineering can apply to any kind of living organism from microorganisms to humans.
Genetic engineering can be applied to humans to replace or supplement defective genes. Where engineering is intended to cure disease, it is called gene therapy. Potential applications that are not related to disease, such as the modification of traits like height, are sometimes called genetic enhancement. Currently, most genetic engineering of humans is done on nonreproductive or somatic cells, like those from bone marrow. The effects of this somatic cell gene therapy are confined to the treated individual. By contrast, germ line gene therapy would modify reproductive cells, so that the modification could be passed on to future generations.
Last Revised: 07/18/03
What Is Genetic Engineering?
Genetic engineering refers to a set of technologies that are being used to change the genetic makeup of cells and move genes across species boundaries to produce novel organisms. The techniques involve highly sophisticated manipulations of genetic material and other biologically important chemicals.
Genes are the chemical blueprints that determine an organism's traits. Moving genes from one organism to another transfers those traits. Through genetic engineering, organisms are given new combinations of genes—and therefore new combinations of traits—that do not occur in nature and, indeed, cannot be developed by natural means. Such an artificial technology is radically different from traditional plant and animal breeding.
Novel organisms
Nature can produce organisms with new gene combinations through sexual reproduction. A brown cow bred to a yellow cow may produce a calf of a completely new color. But reproductive mechanisms limit the number of new combinations. Cows must breed with other cows (or very near relatives). A breeder who wants a purple cow would be able to breed toward one only if the necessary purple genes were available somewhere in a cow or a near relative to cows. A genetic engineer has no such restriction. If purple genes are available anywhere in nature—in a sea urchin or an iris—those genes could be used in attempts to produce purple cows. This unprecedented ability to shuffle genes means that genetic engineers can concoct gene combinations that would never be found in nature.
New risks
Contrary to the arguments made by some proponents, genetic engineering is far from being a minor extension of existing breeding technologies. It is a radically new technology for altering the traits of living organisms by inserting genetic material that has been manipulated by artificial means. Because of this, genetic engineering may one day encompass the routine addition of novel genes that have been wholly synthesized in the laboratory.
Novel organisms bring novel risks, however, as well as the desired benefits. These risks must be carefully assessed to make sure that all effects—both desired and unintended—are benign. UCS advocates caution, examination of alternatives, and careful case-by-case evaluation of genetic enginering applications within an overall framework that seeks to move agricultural systems of food production toward sustainability.
Last Revised: 07/18/03
Biotechnology and the World Food Supply
Today, in a world with abundant food, more than 700 million people are chronically undernourished. Over the next 20 years, the world's population will probably double. The global food supply would need to double just to stay even, but to triple for the larger population to be fed adequately. Meanwhile, we are approaching limits in arable land and productivity and are employing practices that are destroying the soil's capacity to produce food.
Some see biotechnology as the answer to the problem of enabling this much larger population to feed itself. But biotechnology, if by this we mean crops engineered to contain new genes, is not essential. It could play a minor and useful role in developing new agricultural products, but other factors -- including other kinds of breeding technologies -- will be much more important than transgenic crops in determining whether we meet this challenge. It would be a tragedy if other necessary actions were not taken because of a mistaken belief that genetic engineering is some sort of a panacea for hunger. Some of the reasons biotechnology should not be relied on to enable the world to feed itself are outlined below.
More productive crops are only part of the solution to the world's food crisis.
There are many reasons for the current and projected food crisis. Among the most important are lack of income to buy food, lack of infrastructure like roads to get products to market, trade policies that disadvantage farmers in the developing world, lack of inputs such as fertilizer, lack of information, and low-yield farming practices. More productive crops will do little to alleviate hunger if deficiencies in those areas are not addressed as well.
Where more productive crops are needed, there is little reason to believe that genetic engineering will be better than other technologies -- in particular, sophisticated traditional breeding -- at producing higher yielding crops.
Many technologies can increase the yields of crops. These include traditional breeding, production of hybrids, so-called marker-assisted breeding (a sophisticated way of enhancing traditional breeding by knowing which plant cultivars carry which trait), and tissue culture methods for propagating virus-free root stocks. All of these could help improve the productivity of crops in the developing world, but currently only limited resources are available for applying them there.
So far, there no reason to believe that genetic engineering would be markedly better than these more traditional technologies in improving crops. Early "gene dreams" were of nitrogen-fixing crops, higher intrinsic yield, and drought tolerance. But so far none of these seems realistic because most involve complex multigene traits. For the most part, genetically engineered crops are limited to one or two gene transfers and have relative few applications of use to hungry people. Those that are of use, such as insect resistance and virus tolerance, do not increase intrinsic yield and vary in effectiveness. In addition, they appear to be short lived due to the almost certain evolution of resistant pests.
Currently, there is no reason to believe that the limited resources for agricultural development would be better spent on producing genetically engineered crops rather than on applying breeding technologies.
For the most part, genetic engineering techniques are being applied to crops important to the industrialized world, not crops on which the world's hungry depend.
Most genetic engineering in agriculture is being done by large transnational corporations that need to sell their products at premium prices to cover the cost of research. These companies are developing products for farmers in rich countries who can afford to pay high prices for seed. Such farmers are interested in field crops like corn, soybeans, and cotton and fruits like tomatoes and cantaloupes. And that is what the agricultural biotechnology industry is providing. In many cases, genetically engineered fruits are sold at premium prices and seeds are sold with an added technology fee to cover the costs of research. These products are of virtually no value to hungry farmers in Africa, who cannot afford the products of traditional technology, much less these expensive genetically engineered products. In addition, these products are often inappropriate for the developing world because, among other things, they require large amounts of fertilizers, pesticides, and water.
In sum, more productive crops are only part of the solution to the world hunger problem and transgenic crops are not uniquely capable of increasing food production. While some genetically engineered crops will undoubtedly prove useful, there is no reason at this time to invest huge sums in them, especially at the expense of traditional breeding.
What can be done to increase the food supply, particularly for the poor?
Many, many things. At bottom, we need more and better targeted agricultural research. Unlike the past, research can no longer concentrate exclusively on increased production -- it must find ways to minimize the soil erosion, degradation of lakes and rivers, and groundwater pollution that can result from industrial agricultural practices. Growing appreciation of environmentally destructive impacts has led to a renewed interest in agroforestry, intercropping, mixed crop-livestock operations as systems that can increase production with minimal chemical fertilizers and pesticides and a high degree of environmental protection.
Much can be done to promote the sustainable intensification of agricultural production. Most of it should be done in developing countries to enable people to feed themselves so that they do not become dependent on commodities from abroad. All of it depends on local climates, cultures, and economic conditions. Rice farmers in Southeast Asia, for example, are in a far different situation from farmers living at the edge of the Sahara desert. Among the many research areas important for increasing production are the efficient use of irrigation water, crop improvement through traditional plant breeding, and new ways to manage crop-pest interactions, such as integrated pest management.
There is every reason to expect that research along these lines will lead to increased yields. Recently, agricultural scientists working in the Philippines announced that they had used sophisticated traditional breeding techniques to develop a rice variety that increased the proportion of the plant devoted to rice grains in ways that improved rice yields by 20 percent, a stunning achievement considering the importance of rice in the human diet. (Interestingly, the announcement was not accompanied by headlines like "Traditional Crop Breeding Can Feed the World!")
Improvements in other parts of the agricultural system are also essential. These include building and maintaining roads so that farmers can get their crops to market, organizing cooperatives so that farmers can purchase equipment and fertilizer, and reducing post-harvest losses of crops.
Finally, meeting the world food crisis will require changes outside of agriculture like improving the incomes of the poor through microenterprises and shifting the diet of the rich away from excessive dependence on grain-fed livestock. Growing corn to feed cows and chickens is a much less efficient use of limited arable land than growing corn for humans to eat directly.
Last Revised: 10/29/02
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Biotechnology FAQ
1. Is biotechnology necessary for the world to feed itself?
No. Today there is abundant food, yet an eighth of the world's population is chronically undernourished. In the next 20 years, the global population is likely to double. To keep even, the food supply would also have to double, but to feed people adequately it would have to come closer to tripling. This will not be easy: the limits of arable land and productivity are approaching and, at the same time, current agricultural practices are destroying the soil's fertility.
Some believe biotechnology will enable this larger population to feed itself. But biotechnology--especially when taken to mean genetically engineered crops--is not essential to the meeting the challenge. It could play a minor part in developing new agricultural products, but other factors--including traditional breeding technologies and infrastructure improvements--will be much more important. Thus it is important not to pour all resources into developing genetic engineering while neglecting other necessary actions and technology that will do more to address this problem.
2. Isn't biotechnology just a minor extension of traditional breeding technologies?
No. Some biotechnologies, for example marker-assisted breeding, in which breeders take advantage of information about what variety of a species carries which genes, might be considered an extension of traditional breeding technology. But other biotechnologies, such as genetic engineering, would not. Genetic engineering is a radically new technology for altering the traits of living organisms by adding genetic material that has been manipulated outside of cells. No version of traditional plant breeding can add genes from oak trees to wheat, much less genes from horses. Only genetic engineering can accomplish such transfers because only genetic engineering transfers genes by artificial means that disregard natural boundaries. The artificial nature of the technology also allows scientists to rearrange and modify genetic material before transfer and may one day encompass the addition of novel genes that have been wholly synthesized in the laboratory.
3. Is biotechnology more dangerous than other gene transfer technologies?
Not necessarily. So far, we know of no generic harms associated with genetically engineered organisms. For example, it is not true that all genetically engineered foods are toxic or that all released engineered organisms are likely to proliferate in the environment. But specific engineered organisms may be harmful by virtue of the novel combinations of traits they possess. This means the risks of genetically engineered organisms can differ greatly, depending on the particular gene-organism combination, and must therefore be assessed case by case.
In general, of the risks currently associated with genetically engineered organisms, some appear to be unique to such organisms (for example, added allergens in foods) and some overlap those posed by non-engineered organisms (for example, creation of new weeds). Because genetic engineering is a radically new technology, unknown risks may be possible. Lists of potential risks can be generated simply by trying to imagine what could go wrong. It is hard to believe that any current list is complete.
4. Are the currently available genetically engineered crops a major environmental step forward for US agriculture?
No. Genetically engineered crops are currently planted on something like 12 to 15 million acres of US crop land. The most widely planted engineered crops have been developed for two purposes: insect tolerance and herbicide tolerance. Although industry has touted both kinds of crops as having major environmental benefits, a hard look at the products reveals that such benefits are minor at best and likely to be short lived. At bottom, these genetically engineered crops have not put us on a fundamentally different pathway in agriculture and have produced only minor reductions and substitutions in pesticide use in an agriculture that continues to be pesticide-dependent.
5. What is UCS's stance on biotechnology and genetic engineering?
The Union of Concerned Scientists does not support or oppose genetic engineering per se. With respect to some applications, such as the production of pharmaceuticals by genetically engineered bacteria, the benefits are clear and compelling. In the food system, however, we find the risk-benefit calculus more difficult. For example, while it is possible that the planting of genetically engineered crops might reduce some pesticide use over the short term, it is also possible that a new breed of super-resistant weeds will develop, compounding the already difficult task of controlling invasive species.
Because the technology is new, data from field research are scarce. Thus, there is little certainty about either the risks or the benefits from many of the agricultural biotechnology products now entering the marketplace. (For a comprehensive assessment of the current state of research, see "The Ecological Risks and Benefits of Genetically Engineered Plants," Science, 15 December 2000.) And yet, the technology is being commercialized at a rapid pace and on a large scale.
We believe that the federal government must strengthen the regulatory system governing genetically engineered microorganisms, plants, and animals, so that the risks and benefits can be evaluated carefully, case by case, before they come to market. That is the fundamental goal of our program on Food and the Environment, and we are working hard to achieve it.
We also believe that we need better opportunities for civil society to debate the appropriateness of agricultural biotechnology and direct its course. Regulatory programs provide one such opportunity; food labeling represents another. Not only do consumers have the right to know what they are eating, but with labeling they can use purchasing decisions to influence the extent to which producers rely on the technology. Until much more is known about the risks and benefits, this is clearly a prudent course.
Furthermore, we believe in asking whether genetic engineering will enhance or detract from a broader effort that is needed to reduce the harm to our environment caused by modern agriculture. In particular, we believe practices that move agriculture toward greater biological diversity, fewer chemical inputs, and better designed agroecosystems deserve greater attention and more research support.
Last Revised: 11/26/02
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The following articles relating to nanotechnology may be found on the website of How Stuff Works: www.howstuffworks.com
How Nanotechnology Works
by Kevin Bonsor and Jonathan Strickland
Introduction to How Nanotechnology Works
There's an unprecedented multidisciplinary convergence of scientists dedicated to the study of a world so small, we can't see it -- even with a light microscope. That world is the field of nanotechnology, the realm of atoms and nanostructures. Nanotechnology is so new, no one is really sure what will come of it. Even so, predictions range from the ability to reproduce things like diamonds and food to the world being devoured by self-replicating nanorobots.
In order to understand the unusual world of nanotechnology, we need to get an idea of the units of measure involved. A centimeter is one-hundredth of a meter, a millimeter is one-thousandth of a meter, and a micrometer is one-millionth of a meter, but all of these are still huge compared to the nanoscale. A nanometer (nm) is one-billionth of a meter, smaller than the wavelength of visible light and a hundred-thousandth the width of a human hair [source: Berkeley Lab].
Video Gallery: Nanotechnology
Nanotechnology deals with materials and machines on an incredibly tiny scale -- less than one billionth of a meter. To learn more about nanotechnology, check out this HowStuffWorks video.
As small as a nanometer is, it's still large compared to the atomic scale. An atom has a diameter of about 0.1 nm. An atom's nucleus is much smaller -- about 0.00001 nm. Atoms are the building blocks for all matter in our universe. You and everything around you are made of atoms. Nature has perfected the science of manufacturing matter molecularly. For instance, our bodies are assembled in a specific manner from millions of living cells. Cells are nature's nanomachines. At the atomic scale, elements are at their most basic level. On the nanoscale, we can potentially put these atoms together to make almost anything.
In a lecture called "Small Wonders:The World of Nanoscience," Nobel Prize winner Dr. Horst Störmer said that the nanoscale is more interesting than the atomic scale because the nanoscale is the first point where we can assemble something -- it's not until we start putting atoms together that we can make anything useful.
In this article, we'll learn about what nanotechnology means today and what the future of nanotechnology may hold. We'll also look at the potential risks that come with working at the nanoscale.
In the next section, we'll learn more about our world on the nanoscale.
How New is Nanotechnology?
In 1959, physicist and future Nobel prize winner Richard Feynman gave a lecture to the American Physical Society called "There's Plenty of Room at the Bottom." The focus of his speech was about the field of miniaturization and how he believed man would create increasingly smaller, powerful devices.
In 1986, K. Eric Drexler wrote "Engines of Creation" and introduced the term nanotechnology. Scientific research really expanded over the last decade. Inventors and corporations aren't far behind -- today, more than 13,000 patents registered with the U.S. Patent Office have the word "nano" in them [source: U.S. Patent and Trademark Office].
The World of Nanotechnology
Experts sometimes disagree about what constitutes the nanoscale, but in general, you can think of nanotechnology dealing with anything measuring between 1 and 100 nm. Larger than that is the microscale, and smaller than that is the atomic scale.
Sam Yesh/AFP/Getty Images
An engineer prepares a silicon wafer in an early stage of microchip production.
Nanotechnology is rapidly becoming an interdisciplinary field. Biologists, chemists, physicists and engineers are all involved in the study of substances at the nanoscale. Dr. Störmer hopes that the different disciplines develop a common language and communicate with one another [source: Störmer]. Only then, he says, can we effectively teach nanoscience since you can't understand the world of nanotechnology without a solid background in multiple sciences.
One of the exciting and challenging aspects of the nanoscale is the role that quantum mechanics plays in it. The rules of quantum mechanics are very different from classical physics, which means that the behavior of substances at the nanoscale can sometimes contradict common sense by behaving erratically. You can't walk up to a wall and immediately teleport to the other side of it, but at the nanoscale an electron can -- it's called electron tunneling. Substances that are insulators, meaning they can't carry an electric charge, in bulk form might become semiconductors when reduced to the nanoscale. Melting points can change due to an increase in surface area. Much of nanoscience requires that you forget what you know and start learning all over again.
So what does this all mean? Right now, it means that scientists are experimenting with substances at the nanoscale to learn about their properties and how we might be able to take advantage of them in various applications. Engineers are trying to use nano-size wires to create smaller, more powerful microprocessors. Doctors are searching for ways to use nanoparticles in medical applications. Still, we've got a long way to go before nanotechnology dominates the technology and medical markets.
In the next section, we'll look at two important nanotechnology structures: nanowires and carbon nanotubes.
It's a Small World After All
At the nanoscale, objects are so small that we can't see them -- even with a light microscope. Nanoscientists have to use tools like scanning tunneling microscopes or atomic force microscopes to observe anything at the nanoscale. Scanning tunneling microscopes use a weak electric current to probe the scanned material. Atomic force microscopes scan surfaces with an incredibly fine tip. Both microscopes send data to a computer, which can assemble the information and project it graphically onto a monitor [source: Encyclopædia Britannica].
Nanowires and Carbon Nanotubes
Currently, scientists find two nano-size structures of particular interest: nanowires and carbon nanotubes. Nanowires are wires with a very small diameter, sometimes as small as 1 nanometer. Scientists hope to use them to build tiny transistors for computer chips and other electronic devices. In the last couple of years, carbon nanotubes have overshadowed nanowires. We're still learning about these structures, but what we've learned so far is very exciting.
A carbon nanotube is a nano-size cylinder of carbon atoms. Imagine a sheet of carbon atoms, which would look like a sheet of hexagons. If you roll that sheet into a tube, you'd have a carbon nanotube. Carbon nanotube properties depend on how you roll the sheet. In other words, even though all carbon nanotubes are made of carbon, they can be very different from one another based on how you align the individual atoms.
With the right arrangement of atoms, you can create a carbon nanotube that's hundreds of times stronger than steel, but six times lighter [source: The Ecologist]. Engineers plan to make building material out of carbon nanotubes, particularly for things like cars and airplanes. Lighter vehicles would mean better fuel efficiency, and the added strength translates to increased passenger safety.
Carbon nanotubes can also be effective semiconductors with the right arrangement of atoms. Scientists are still working on finding ways to make carbon nanotubes a realistic option for transistors in microprocessors and other electronics.
In the next section, we'll look at products that are taking advantage of nanotechnology.
Graphite vs. Diamonds
What's the difference between graphite and diamonds? Both materials are made of carbon, but both have vastly different properties. Graphite is soft; diamonds are hard. Graphite conducts electricity, but diamonds are insulators and can't conduct electricity. Graphite is opaque; diamonds are usually transparent. Graphite and diamonds have these properties because of the way the carbon atoms bond together at the nanoscale.
Products with Nanotechnology
You might be surprised to find out how many products on the market are already benefiting from nanotechnology.
· Greg Wood/AFP/Getty Images
Ingredients like zinc oxide can leave a white sheen behind. But sunscreens with zinc oxide nanoparticles rub on clear.
· Sunscreen - Many sunscreens contain nanoparticles of zinc oxide or titanium oxide. Older sunscreen formulas use larger particles, which is what gives most sunscreens their whitish color. Smaller particles are less visible, meaning that when you rub the sunscreen into your skin, it doesn't give you a whitish tinge.
· Self-cleaning glass - A company called Pilkington offers a product they call Activ Glass, which uses nanoparticles to make the glass photocatalytic and hydrophilic. The photocatalytic effect means that when UV radiation from light hits the glass, nanoparticles become energized and begin to break down and loosen organic molecules on the glass (in other words, dirt). Hydrophilic means that when water makes contact with the glass, it spreads across the glass evenly, which helps wash the glass clean.
· Clothing - Scientists are using nanoparticles to enhance your clothing. By coating fabrics with a thin layer of zinc oxide nanoparticles, manufacturers can create clothes that give better protection from UV radiation. Some clothes have nanoparticles in the form of little hairs or whiskers that help repel water and other materials, making the clothing stain-resistant.
· Yoshikazu Tsuno/AFP/Getty Images
Bridgestone engineers developed this Quick Response Liquid Powder Display, a flexible digital screen, using nanotechnology.
· Scratch-resistant coatings - Engineers discovered that adding aluminum silicate nanoparticles to scratch-resistant polymer coatings made the coatings more effective, increasing resistance to chipping and scratching. Scratch-resistant coatings are common on everything from cars to eyeglass lenses.
· Antimicrobial bandages - Scientist Robert Burrell created a process to manufacture antibacterial bandages using nanoparticles of silver. Silver ions block microbes' cellular respiration [source: Burnsurgery.org]. In other words, silver smothers harmful cells, killing them.
· Swimming pool cleaners and disinfectants - EnviroSystems, Inc. developed a mixture (called a nanoemulsion) of nano-sized oil drops mixed with a bactericide. The oil particles adhere to bacteria, making the delivery of the bactericide more efficient and effective.
[source: The Ecologist]
New products incorporating nanotechnology are coming out every day. Wrinkle-resistant fabrics, deep-penetrating cosmetics, liquid crystal displays (LCD) and other conveniences using nanotechnology are on the market. Before long, we'll see dozens of other products that take advantage of nanotechnology ranging from Intel microprocessors to bio-nanobatteries, capacitors only a few nanometers thick. While this is exciting, it's only the tip of the iceberg as far as how nanotechnology may impact us in the future.
In the next section, we'll look at some of the incredible things that nanotechnology may hold for us.
Tennis, Anyone?
Nanotechnology is making a big impact on the tennis world. In 2002, the tennis racket company Babolat introduced the VS Nanotube Power racket. They made the racket out of carbon nanotube-infused graphite, meaning the racket was very light, yet many times stronger than steel. Meanwhile, tennis ball manufacturer Wilson introduced the Double Core tennis ball. These balls have a coating of clay nanoparticles on the inner core. The clay acts as a sealant, making it very difficult for air to escape the ball.
The Future of Nanotechnology
In the world of "Star Trek," machines called replicators can produce practically any physical object, from weapons to a steaming cup of Earl Grey tea. Long considered to be exclusively the product of science fiction, today some people believe replicators are a very real possibility. They call it molecular manufacturing, and if it ever does become a reality, it could drastically change the world.
Atoms and molecules stick together because they have complementary shapes that lock together, or charges that attract. Just like with magnets, a positively charged atom will stick to a negatively charged atom. As millions of these atoms are pieced together by nanomachines, a specific product will begin to take shape. The goal of molecular manufacturing is to manipulate atoms individually and place them in a pattern to produce a desired structure.
The first step would be to develop nanoscopic machines, called assemblers, that scientists can program to manipulate atoms and molecules at will. Rice University Professor Richard Smalley points out that it would take a single nanoscopic machine millions of years to assemble a meaningful amount of material. In order for molecular manufacturing to be practical, you would need trillions of assemblers working together simultaneously. Eric Drexler believes that assemblers could first replicate themselves, building other assemblers. Each generation would build another, resulting in exponential growth until there are enough assemblers to produce objects [source: Ray Kurzweil].
Assemblers might have moving parts like the nanogears
in this concept drawing.
Trillions of assemblers and replicators could fill an area smaller than a cubic millimeter, and could still be too small for us to see with the naked eye. Assemblers and replicators could work together to automatically construct products, and could eventually replace all traditional labor methods. This could vastly decrease manufacturing costs, thereby making consumer goods plentiful, cheaper and stronger. Eventually, we could be able to replicate anything, including diamonds, water and food. Famine could be eradicated by machines that fabricate foods to feed the hungry.
Nanotechnology may have its biggest impact on the medical industry. Patients will drink fluids containing nanorobots programmed to attack and reconstruct the molecular structure of cancer cells and viruses. There's even speculation that nanorobots could slow or reverse the aging process, and life expectancy could increase significantly. Nanorobots could also be programmed to perform delicate surgeries -- such nanosurgeons could work at a level a thousand times more precise than the sharpest scalpel [source: International Journal of Surgery]. By working on such a small scale, a nanorobot could operate without leaving the scars that conventional surgery does. Additionally, nanorobots could change your physical appearance. They could be programmed to perform cosmetic surgery, rearranging your atoms to change your ears, nose, eye color or any other physical feature you wish to alter.
Nanotechnology has the potential to have a positive effect on the environment. For instance, scientists could program airborne nanorobots to rebuild the thinning ozone layer. Nanorobots could remove contaminants from water sources and clean up oil spills. Manufacturing materials using the bottom-up method of nanotechnology also creates less pollution than conventional manufacturing processes. Our dependence on non-renewable resources would diminish with nanotechnology. Cutting down trees, mining coal or drilling for oil may no longer be necessary -- nanomachines could produce those resources.
Many nanotechnology experts feel that these applications are well outside the realm of possibility, at least for the foreseeable future. They caution that the more exotic applications are only theoretical. Some worry that nanotechnology will end up like virtual reality -- in other words, the hype surrounding nanotechnology will continue to build until the limitations of the field become public knowledge, and then interest (and funding) will quickly dissipate.
In the next section, we'll look at some of the challenges and risks of nanotechnology.
Nanotechnology Challenges, Risks and Ethics
The most immediate challenge in nanotechnology is that we need to learn more about materials and their properties at the nanoscale. Universities and corporations across the world are rigorously studying how atoms fit together to form larger structures. We're still learning about how quantum mechanics impact substances at the nanoscale.
Because elements at the nanoscale behave differently than they do in their bulk form, there's a concern that some nanoparticles could be toxic. Some doctors worry that the nanoparticles are so small, that they could easily cross the blood-brain barrier, a membrane that protects the brain from harmful chemicals in the bloodstream. If we plan on using nanoparticles to coat everything from our clothing to our highways, we need to be sure that they won't poison us.
Closely related to the knowledge barrier is the technical barrier. In order for the incredible predictions regarding nanotechnology to come true, we have to find ways to mass produce nano-size products like transistors and nanowires. While we can use nanoparticles to build things like tennis rackets and make wrinkle-free fabrics, we can't make really complex microprocessor chips with nanowires yet.
Apocalyptic Goo
Eric Drexler, the man who introduced the word nanotechnology, presented a frightening apocalyptic vision -- self-replicating nanorobots malfunctioning, duplicating themselves a trillion times over, rapidly consuming the entire world as they pull carbon from the environment to build more of themselves. It's called the "grey goo" scenario, where a synthetic nano-size device replaces all organic material. Another scenario involves nanodevices made of organic material wiping out the Earth -- the "green goo" scenario.
There are some hefty social concerns about nanotechnology too. Nanotechnology may also allow us to create more powerful weapons, both lethal and non-lethal. Some organizations are concerned that we'll only get around to examining the ethical implications of nanotechnology in weaponry after these devices are built. They urge scientists and politicians to examine carefully all the possibilities of nanotechnology before designing increasingly powerful weapons.
If nanotechnology in medicine makes it possible for us to enhance ourselves physically, is that ethical? In theory, medical nanotechnology could make us smarter, stronger and give us other abilities ranging from rapid healing to night vision. Should we pursue such goals? Could we continue to call ourselves human, or would we become transhuman -- the next step on man's evolutionary path? Since almost every technology starts off as very expensive, would this mean we'd create two races of people -- a wealthy race of modified humans and a poorer population of unaltered people? We don't have answers to these questions, but several organizations are urging nanoscientists to consider these implications now, before it becomes too late.
Not all questions involve altering the human body -- some deal with the world of finance and economics. If molecular manufacturing becomes a reality, how will that impact the world's economy? Assuming we can build anything we need with the click of a button, what happens to all the manufacturing jobs? If you can create anything using a replicator, what happens to currency? Would we move to a completely electronic economy? Would we even need money?
Whether we'll actually need to answer all of these questions is a matter of debate. Many experts think that concerns like grey goo and transhumans are at best premature, and probably unnecessary. Even so, nanotechnology will definitely continue to impact us as we learn more about the enormous potential of the nanoscale.
The following articles relating to biotechnology and genetic engineering may be found on the website of the Union of Concerned Scientists: www.ucsusa.org
What Is Biotechnology?
Biotechnology is a broad term that applies to all practical uses of living organisms—anything from microorganisms used in the fermentation of beer to the most sophisticated application of gene therapy. The term covers applications that are old and new, familiar and strange, sophisticated and simple.
Defined in this way, the term is almost too broad to be useful. One way of thinking about biotechnology is to consider two categories of activities: those that are traditional and familiar and those that are relatively new. Within each category can be found technologies that are genetic—that involve modifications of traits passed down from one generation to the next—and technologies that are not.
Although there are interesting issues connected with a number of biotechnologies—both old and new—most of UCS's work focuses on genetic engineering, a new genetic biotechnology.
Traditional Biotechnologies
A prime example of traditional genetic biotechnologies is selective breeding of plants and animals. The rudiments of selecting plants and animals with desirable traits and breeding them under controlled conditions probably go back to the dawn of civilization, but the expansion of knowledge about genetics and biology in this century has developed selective breeding into a powerful and sophisticated technology. New molecular approaches like marker-assisted breeding (which enhances traditional breeding through knowledge of which cultivars or breeds carry which trait) promise to enhance these approaches even further.
Traditional breeding technologies have been immensely successful, and indeed are largely responsible for the high yields associated with contemporary agriculture. These technologies should not be considered passé or out of date. For multigene traits like intrinsic yield and drought resistance, they surpass genetic engineering. This is because selective breeding operates on whole organisms—complete sets of coordinated genes—while genetic engineering is restricted to three or four gene transfers with little control over where the new genes are inserted. For the most important agronomic traits, traditional breeding remains the technology of choice.
Other traditional nongenetic biotechnologies include the fermentation of microorganisms to produce wine, beer, and cheese. Industry also uses microorganisms to produce various products such as enzymes for use in laundry detergents. In an effort to find microorganisms that produce large amounts of enzymes, scientists sometimes treat a batch of organisms with radiation or chemicals to randomly produce genetic alternations. The process, called mutagenesis, produces numerous genetic changes in the bacteria, among which might be a few that produce more of the desired product.
New Biotechnologies
Many new biotechnologies do not involve modifications of traits passed on to the next generation. A good example is monoclonal antibodies (highly specific preparations of antibodies that bind to a single site on a protein), which have many diagnostic applications, including home pregnancy testing kits. Many biotechnology companies are engaged in these sophisticated, but noncontroversial, technologies.
By contrast, mammalian cloning is a new biotechnology that does not involve gene modification, but is nevertheless highly controversial. Cloning reproduces adult mammals by transplanting a nucleus from adult cells into an egg from which the nucleus has been removed and allowing the egg to develop in a surrogate manner. The resulting individuals are as similar to the adults from which the nuclei were taken as identical twins are to one another. Although this procedure has profound implications for human reproduction, it does not modify specific traits of an individual, but rather transfers a whole nucleus containing a complete set of genetic information.
The new technology that can affect future generations is genetic engineering, a technology based on the artificial manipulation and transfer of genetic material. This technology can move genes and the traits they dictate across natural boundaries—from one type of plant to another, from one type of animal to another, and even from a plant to an animal or an animal to a plant. Cells modified by these techniques pass the new genes and traits on to their offspring. Genetic engineering can apply to any kind of living organism from microorganisms to humans.
Genetic engineering can be applied to humans to replace or supplement defective genes. Where engineering is intended to cure disease, it is called gene therapy. Potential applications that are not related to disease, such as the modification of traits like height, are sometimes called genetic enhancement. Currently, most genetic engineering of humans is done on nonreproductive or somatic cells, like those from bone marrow. The effects of this somatic cell gene therapy are confined to the treated individual. By contrast, germ line gene therapy would modify reproductive cells, so that the modification could be passed on to future generations.
Last Revised: 07/18/03
What Is Genetic Engineering?
Genetic engineering refers to a set of technologies that are being used to change the genetic makeup of cells and move genes across species boundaries to produce novel organisms. The techniques involve highly sophisticated manipulations of genetic material and other biologically important chemicals.
Genes are the chemical blueprints that determine an organism's traits. Moving genes from one organism to another transfers those traits. Through genetic engineering, organisms are given new combinations of genes—and therefore new combinations of traits—that do not occur in nature and, indeed, cannot be developed by natural means. Such an artificial technology is radically different from traditional plant and animal breeding.
Novel organisms
Nature can produce organisms with new gene combinations through sexual reproduction. A brown cow bred to a yellow cow may produce a calf of a completely new color. But reproductive mechanisms limit the number of new combinations. Cows must breed with other cows (or very near relatives). A breeder who wants a purple cow would be able to breed toward one only if the necessary purple genes were available somewhere in a cow or a near relative to cows. A genetic engineer has no such restriction. If purple genes are available anywhere in nature—in a sea urchin or an iris—those genes could be used in attempts to produce purple cows. This unprecedented ability to shuffle genes means that genetic engineers can concoct gene combinations that would never be found in nature.
New risks
Contrary to the arguments made by some proponents, genetic engineering is far from being a minor extension of existing breeding technologies. It is a radically new technology for altering the traits of living organisms by inserting genetic material that has been manipulated by artificial means. Because of this, genetic engineering may one day encompass the routine addition of novel genes that have been wholly synthesized in the laboratory.
Novel organisms bring novel risks, however, as well as the desired benefits. These risks must be carefully assessed to make sure that all effects—both desired and unintended—are benign. UCS advocates caution, examination of alternatives, and careful case-by-case evaluation of genetic enginering applications within an overall framework that seeks to move agricultural systems of food production toward sustainability.
Last Revised: 07/18/03
Biotechnology and the World Food Supply
Today, in a world with abundant food, more than 700 million people are chronically undernourished. Over the next 20 years, the world's population will probably double. The global food supply would need to double just to stay even, but to triple for the larger population to be fed adequately. Meanwhile, we are approaching limits in arable land and productivity and are employing practices that are destroying the soil's capacity to produce food.
Some see biotechnology as the answer to the problem of enabling this much larger population to feed itself. But biotechnology, if by this we mean crops engineered to contain new genes, is not essential. It could play a minor and useful role in developing new agricultural products, but other factors -- including other kinds of breeding technologies -- will be much more important than transgenic crops in determining whether we meet this challenge. It would be a tragedy if other necessary actions were not taken because of a mistaken belief that genetic engineering is some sort of a panacea for hunger. Some of the reasons biotechnology should not be relied on to enable the world to feed itself are outlined below.
More productive crops are only part of the solution to the world's food crisis.
There are many reasons for the current and projected food crisis. Among the most important are lack of income to buy food, lack of infrastructure like roads to get products to market, trade policies that disadvantage farmers in the developing world, lack of inputs such as fertilizer, lack of information, and low-yield farming practices. More productive crops will do little to alleviate hunger if deficiencies in those areas are not addressed as well.
Where more productive crops are needed, there is little reason to believe that genetic engineering will be better than other technologies -- in particular, sophisticated traditional breeding -- at producing higher yielding crops.
Many technologies can increase the yields of crops. These include traditional breeding, production of hybrids, so-called marker-assisted breeding (a sophisticated way of enhancing traditional breeding by knowing which plant cultivars carry which trait), and tissue culture methods for propagating virus-free root stocks. All of these could help improve the productivity of crops in the developing world, but currently only limited resources are available for applying them there.
So far, there no reason to believe that genetic engineering would be markedly better than these more traditional technologies in improving crops. Early "gene dreams" were of nitrogen-fixing crops, higher intrinsic yield, and drought tolerance. But so far none of these seems realistic because most involve complex multigene traits. For the most part, genetically engineered crops are limited to one or two gene transfers and have relative few applications of use to hungry people. Those that are of use, such as insect resistance and virus tolerance, do not increase intrinsic yield and vary in effectiveness. In addition, they appear to be short lived due to the almost certain evolution of resistant pests.
Currently, there is no reason to believe that the limited resources for agricultural development would be better spent on producing genetically engineered crops rather than on applying breeding technologies.
For the most part, genetic engineering techniques are being applied to crops important to the industrialized world, not crops on which the world's hungry depend.
Most genetic engineering in agriculture is being done by large transnational corporations that need to sell their products at premium prices to cover the cost of research. These companies are developing products for farmers in rich countries who can afford to pay high prices for seed. Such farmers are interested in field crops like corn, soybeans, and cotton and fruits like tomatoes and cantaloupes. And that is what the agricultural biotechnology industry is providing. In many cases, genetically engineered fruits are sold at premium prices and seeds are sold with an added technology fee to cover the costs of research. These products are of virtually no value to hungry farmers in Africa, who cannot afford the products of traditional technology, much less these expensive genetically engineered products. In addition, these products are often inappropriate for the developing world because, among other things, they require large amounts of fertilizers, pesticides, and water.
In sum, more productive crops are only part of the solution to the world hunger problem and transgenic crops are not uniquely capable of increasing food production. While some genetically engineered crops will undoubtedly prove useful, there is no reason at this time to invest huge sums in them, especially at the expense of traditional breeding.
What can be done to increase the food supply, particularly for the poor?
Many, many things. At bottom, we need more and better targeted agricultural research. Unlike the past, research can no longer concentrate exclusively on increased production -- it must find ways to minimize the soil erosion, degradation of lakes and rivers, and groundwater pollution that can result from industrial agricultural practices. Growing appreciation of environmentally destructive impacts has led to a renewed interest in agroforestry, intercropping, mixed crop-livestock operations as systems that can increase production with minimal chemical fertilizers and pesticides and a high degree of environmental protection.
Much can be done to promote the sustainable intensification of agricultural production. Most of it should be done in developing countries to enable people to feed themselves so that they do not become dependent on commodities from abroad. All of it depends on local climates, cultures, and economic conditions. Rice farmers in Southeast Asia, for example, are in a far different situation from farmers living at the edge of the Sahara desert. Among the many research areas important for increasing production are the efficient use of irrigation water, crop improvement through traditional plant breeding, and new ways to manage crop-pest interactions, such as integrated pest management.
There is every reason to expect that research along these lines will lead to increased yields. Recently, agricultural scientists working in the Philippines announced that they had used sophisticated traditional breeding techniques to develop a rice variety that increased the proportion of the plant devoted to rice grains in ways that improved rice yields by 20 percent, a stunning achievement considering the importance of rice in the human diet. (Interestingly, the announcement was not accompanied by headlines like "Traditional Crop Breeding Can Feed the World!")
Improvements in other parts of the agricultural system are also essential. These include building and maintaining roads so that farmers can get their crops to market, organizing cooperatives so that farmers can purchase equipment and fertilizer, and reducing post-harvest losses of crops.
Finally, meeting the world food crisis will require changes outside of agriculture like improving the incomes of the poor through microenterprises and shifting the diet of the rich away from excessive dependence on grain-fed livestock. Growing corn to feed cows and chickens is a much less efficient use of limited arable land than growing corn for humans to eat directly.
Last Revised: 10/29/02
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Biotechnology FAQ
1. Is biotechnology necessary for the world to feed itself?
No. Today there is abundant food, yet an eighth of the world's population is chronically undernourished. In the next 20 years, the global population is likely to double. To keep even, the food supply would also have to double, but to feed people adequately it would have to come closer to tripling. This will not be easy: the limits of arable land and productivity are approaching and, at the same time, current agricultural practices are destroying the soil's fertility.
Some believe biotechnology will enable this larger population to feed itself. But biotechnology--especially when taken to mean genetically engineered crops--is not essential to the meeting the challenge. It could play a minor part in developing new agricultural products, but other factors--including traditional breeding technologies and infrastructure improvements--will be much more important. Thus it is important not to pour all resources into developing genetic engineering while neglecting other necessary actions and technology that will do more to address this problem.
2. Isn't biotechnology just a minor extension of traditional breeding technologies?
No. Some biotechnologies, for example marker-assisted breeding, in which breeders take advantage of information about what variety of a species carries which genes, might be considered an extension of traditional breeding technology. But other biotechnologies, such as genetic engineering, would not. Genetic engineering is a radically new technology for altering the traits of living organisms by adding genetic material that has been manipulated outside of cells. No version of traditional plant breeding can add genes from oak trees to wheat, much less genes from horses. Only genetic engineering can accomplish such transfers because only genetic engineering transfers genes by artificial means that disregard natural boundaries. The artificial nature of the technology also allows scientists to rearrange and modify genetic material before transfer and may one day encompass the addition of novel genes that have been wholly synthesized in the laboratory.
3. Is biotechnology more dangerous than other gene transfer technologies?
Not necessarily. So far, we know of no generic harms associated with genetically engineered organisms. For example, it is not true that all genetically engineered foods are toxic or that all released engineered organisms are likely to proliferate in the environment. But specific engineered organisms may be harmful by virtue of the novel combinations of traits they possess. This means the risks of genetically engineered organisms can differ greatly, depending on the particular gene-organism combination, and must therefore be assessed case by case.
In general, of the risks currently associated with genetically engineered organisms, some appear to be unique to such organisms (for example, added allergens in foods) and some overlap those posed by non-engineered organisms (for example, creation of new weeds). Because genetic engineering is a radically new technology, unknown risks may be possible. Lists of potential risks can be generated simply by trying to imagine what could go wrong. It is hard to believe that any current list is complete.
4. Are the currently available genetically engineered crops a major environmental step forward for US agriculture?
No. Genetically engineered crops are currently planted on something like 12 to 15 million acres of US crop land. The most widely planted engineered crops have been developed for two purposes: insect tolerance and herbicide tolerance. Although industry has touted both kinds of crops as having major environmental benefits, a hard look at the products reveals that such benefits are minor at best and likely to be short lived. At bottom, these genetically engineered crops have not put us on a fundamentally different pathway in agriculture and have produced only minor reductions and substitutions in pesticide use in an agriculture that continues to be pesticide-dependent.
5. What is UCS's stance on biotechnology and genetic engineering?
The Union of Concerned Scientists does not support or oppose genetic engineering per se. With respect to some applications, such as the production of pharmaceuticals by genetically engineered bacteria, the benefits are clear and compelling. In the food system, however, we find the risk-benefit calculus more difficult. For example, while it is possible that the planting of genetically engineered crops might reduce some pesticide use over the short term, it is also possible that a new breed of super-resistant weeds will develop, compounding the already difficult task of controlling invasive species.
Because the technology is new, data from field research are scarce. Thus, there is little certainty about either the risks or the benefits from many of the agricultural biotechnology products now entering the marketplace. (For a comprehensive assessment of the current state of research, see "The Ecological Risks and Benefits of Genetically Engineered Plants," Science, 15 December 2000.) And yet, the technology is being commercialized at a rapid pace and on a large scale.
We believe that the federal government must strengthen the regulatory system governing genetically engineered microorganisms, plants, and animals, so that the risks and benefits can be evaluated carefully, case by case, before they come to market. That is the fundamental goal of our program on Food and the Environment, and we are working hard to achieve it.
We also believe that we need better opportunities for civil society to debate the appropriateness of agricultural biotechnology and direct its course. Regulatory programs provide one such opportunity; food labeling represents another. Not only do consumers have the right to know what they are eating, but with labeling they can use purchasing decisions to influence the extent to which producers rely on the technology. Until much more is known about the risks and benefits, this is clearly a prudent course.
Furthermore, we believe in asking whether genetic engineering will enhance or detract from a broader effort that is needed to reduce the harm to our environment caused by modern agriculture. In particular, we believe practices that move agriculture toward greater biological diversity, fewer chemical inputs, and better designed agroecosystems deserve greater attention and more research support.
Last Revised: 11/26/02
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